Agencies (Qasioun) - Isco scored twice as a scintillating Spain beat Italy at the Bernabeu to take a huge step towards qualifying for the World Cup from Group G.
The Real Madrid playmaker curled home a free-kick and then smashed in a second as Spain named no recognised striker.
Chelsea's Alvaro Morata came on to add a third from Sergio Ramos' cross.
Italy, who had not lost a qualifier since 2004, trail Spain by three points with a much worse goal difference and are likely to be in the play-offs.
Only the winners of each group qualify directly for Russia, with the eight best ranked second-placed teams playing off.